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78. Mohanty A, Nam A, Srivastava S, Jones J, Lomenick B, Singhal SS, Guo L, Cho H, Li A, Behal A, Mirzapoiazova T, Massarelli E, Koczywas M, Arvanitis LD, Walser T, Villaflor V, Hamilton S, Mambetsariev I, Sattler M, Nasser MW, Jain M, Batra SK, Soldi R, Sharma S, Fakih M, Mohanty SK, Mainan A, Wu X, Chen Y, He Y, Chou, T.-F., Roy S, Orban J, Kulkarni P, Salgia R. Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer. Sci Adv. 2023 Oct 13;9(41):eade3816. doi: Epub 2023 Oct 13. PMID: 37831779; PMCID: PMC10575592.

77. Luzzi A, Wang F, Li S, Iacovino M, Chou, T.-F. Skeletal muscle cell protein dysregulation highlights the pathogenesis mechanism of myopathy-associated p97/VCP R155H mutations. Front Neurol. 2023 Aug 3;14:1211635. doi: PMID: 37602234; PMCID: PMC10435852.

76. Schiava M, Ikenaga C, Topf A, Caballero-Ávila M, Chou, T.-F, Li S, Wang F, Daw J, Stojkovic T, Villar-Quiles R, Nishino I, Inoue M, Nishimori Y, Saito Y, Katsuno M, Noda S, Ito C, Otsuka M, Nahir S, Manousakis G, Walk D, Quinn C, Alfano L, Sahenk Z, Tasca G, Monforte M, Sabatelli M, Bisogni G, Oldfors A, Rydeliu A, Pal E, Paradas C, Velez B, De Bleecker JL, Farugia ME, Longman C, Harms MB, Ralston S, Zanoteli E, Macedo Serafim da Silva A, Sotoca J, Juntas-Morales R, Bevilacqua J, Balart M, Talbot S, Straub V, Guglieri M, Marini-Bettolo C, Diaz-Manera J, Weihl CC. Clinical Classification of Variants in the Valosin-Containing Protein Gene Associated With Multisystem Proteinopathy. Neurol Genet. 2023 Aug 15;9(5):e200093. doi: PMID: 37588275; PMCID: PMC10427110.

75. LaPorte MG, Alverez C, Chatterley A, Kovaliov M, Carder EJ, Houghton MJ, Lim C, Miller ER, Samankumara LP, Liang M, Kerrigan K, Yue Z, Li S, Tomaino F, Wang F, Green N, Stott GM, Srivastava A, Chou, T.-F, Wipf P, Huryn DM. Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer. ACS Med Chem Lett. 2023 Jun 21;14(7):977-985. doi: PMID: 37465292; PMCID: PMC10351062.

74. Gupta, A., Lu, C., Wang, F., Chou, T. F., & Shan, S. O. (2023). An ankyrin repeat chaperone targets toxic oligomers during amyloidogenesis. Protein science : a publication of the Protein Society, e4728. doi: Advance online publication. PMID: 37433015.

73. Tu, J., Min, J., Song, Y., Xu, C., Li, J., Moore, J., Hanson, J., Hu, E., Parimon, T., Wang, T. Y., Davoodi, E., Chou, T. F., Chen, P., Hsu, J. J., Rossiter, H. B., & Gao, W. (2023). A wireless patch for the monitoring of C-reactive protein in sweat. Nature biomedical engineering, 10.1038/s41551-023-01059-5. doi: Advance online publication. PMID: 37349389

72. Findlay, A. R., Paing, M. M., Daw, J. A., Haller, M., Bengoechea, R., Pittman, S. K., Li, S., Wang, F., Miller, T. M., True, H. L., Chou, T. F., & Weihl, C. C. (2023). DNAJB6 isoform specific knockdown: Therapeutic potential for limb girdle muscular dystrophy D1. Molecular therapy. Nucleic acids, 32, 937–948. doi: PMID: 37346979; PMCID: PMC10280091.

71. Jones, J., MacKrell, E. J., Wang, T. Y., Lomenick, B., Roukes, M. L., & Chou, T. F. (2023). Tidyproteomics: an open-source R package and data object for quantitative proteomics post analysis and visualization. BMC bioinformatics, 24(1), 239. doi: PMID: 37280522; PMCID: PMC10246047.

70. Rosencrans, W. M., Queralt-Martin, M., Lessen, H. J., Larimi, M. G., Rajendran, M., Chou, T. F., Mahalakshmi, R., Sodt, A. J., Yu, T. Y., Bezrukov, S. M., & Rostovtseva, T. K. (2023). Defining the roles and regulation of the mitochondrial VDAC isoforms one molecule at a time. Biophysical journal, 122(3), 93a. doi: PMID: 37220506; PMCID: PMC7614561.

69. Dutka, P., Metskas, L. A., Hurt, R. C., Salahshoor, H., Wang, T. Y., Malounda, D., Lu, G. J., Chou, T. F., Shapiro, M. G., & Jensen, G. J. (2023). Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET. Structure (London, England : 1993), 31(5), 518–528.e6. doi: 10.1016/j.str.2023.03.011. PMID: 37040766; PMCID: PMC10185304.

68. Le Guerroué, F., Bunker, E. N., Rosencrans, W. M., Nguyen, J. T., Basar, M. A., Werner, A., Chou, T. F., Wang, C., & Youle, R. J. (2023). TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. Molecular cell, 83(6), 927–941.e8. doi: 10.1016/j.molcel.2023.02.023. PMID: 36898370; PMCID: PMC10112281.

67. Tan, C. H., Cheng, K. W., Park, H., Sternberg, P. W., & Chou, T. F. (2023). LINKIN-associated proteins necessary for tissue integrity during collective cell migration. bioRxiv : the preprint server for biology, 2023.02.08.527750. doi: 10.1101/2023.02.08.527750. PMID: 36798316; PMCID: PMC9934607.

66. Wang, G. Z., Warren, E. A., Haas, A. L., Peña, A. S., Kiedrowski, M. R., Lomenick, B., Chou, T. F., Bomberger, J. M., Tirrell, D. A., & Limoli, D. H. (2023). Staphylococcal secreted cytotoxins are competition sensing signals for Pseudomonas aeruginosa. bioRxiv : the preprint server for biology, 2023.01.29.526047. doi: 10.1101/2023.01.29.526047. PMID: 36747623; PMCID: PMC9900984.


65. Spero, M. A., Jones, J., Lomenick, B., Chou, T. F., & Newman, D. K. (2022). Mechanisms of chlorate toxicity and resistance in Pseudomonas aeruginosa. Molecular microbiology, 118(4), 321–335. doi: 10.1111/mmi.14972. PMID: 36271736; PMCID: PMC9589919.

64. Guna, A., Stevens, T. A., Inglis, A. J., Replogle, J. M., Esantsi, T. K., Muthukumar, G., Shaffer, K. C. L., Wang, M. L., Pogson, A. N., Jones, J. J., Lomenick, B., Chou, T. F., Weissman, J. S., & Voorhees, R. M. (2022). MTCH2 is a mitochondrial outer membrane protein insertase. Science (New York, N.Y.), 378(6617), 317–322. doi: 10.1126/science.add1856. PMID: 36264797; PMCID: PMC9674023.

63. Puskar, R., Du Truong, C., Swain, K., Chowdhury, S., Chan, K. Y., Li, S., Cheng, K. W., Wang, T. Y., Poh, Y. P., Mazor, Y., Liu, H., Chou, T. F., Nannenga, B. L., & Chiu, P. L. (2022). Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria. Nature communications, 13(1), 5824. doi: PMID: 36192412; PMCID: PMC9529944.

62. Yang CI, Zhu Z, Jones JJ, Lomenick B, Chou TF, Shan SO. System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity. iScience. 2022 Jul 15;25(8):104756. doi: 10.1016/j.isci.2022.104756. PMID: 35942092; PMCID: PMC9356101.

61. LeBlanc AK, Mazcko CN, Fan TM, Vail DM, Flesner BK, Bryan JN, Li S, Wang F, Harris S, Vargas JD, Govindharajulu JP, Jaganathan S, Tomaino F, Srivastava AK, Chou TF, Stott GM, Covey JM, Mroczkowski B, Doroshow JH. Comparative oncology assessment of a novel inhibitor of valosin-containing protein in tumor-bearing dogs. Mol Cancer Ther. 2022 Jul 25:MCT-22-0167. doi: Epub ahead of print. PMID: 35876604.

60. Wang F, Li S, Wang TY, Lopez GA, Antoshechkin I, Chou TF. P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration. Brain Commun. 2022 Jul 6;4(4):fcac176. doi: PMID: 35865348; PMCID: PMC9294923.

59. Ravanfar R, Sheng Y, Shahgholi M, Lomenick B, Jones J, Chou TF, Gray HB, Winkler JR. Surface cysteines could protect the SARS-CoV-2 main protease from oxidative damage. J Inorg Biochem. 2022 Sep;234:111886. doi: 10.1016/j.jinorgbio.2022.111886. Epub 2022 Jun 2. PMID: 35675741; PMCID: PMC9161685.

58. Li S, Wang F, Zhang G, Chou TF. NMS-873 Leads to Dysfunctional Glycometabolism in A p97-Independent Manner in HCT116 Colon Cancer Cells. Pharmaceutics. 2022 Mar 31;14(4):764. doi: 10.3390/pharmaceutics14040764. PMID: 35456598; PMCID: PMC9024726.

57. Wang F, Li S, Rosencrans WM, Cheng KW, Stott GM, Mroczkowski B, Chou TF. Sulforaphane is Synergistic with CB-5083 and Inhibits Colony Formation of CB-5083-Resistant HCT116 Cells. ChemMedChem. 2022 Jun 3;17(11):e202200030. doi: 10.1002/cmdc.202200030. Epub 2022 Apr 22. PMID: 35451199.

56. Wang F, Li S, Cheng KW, Rosencrans WM, Chou TF. The p97 Inhibitor UPCDC-30245 Blocks Endo-Lysosomal Degradation. Pharmaceuticals (Basel). 2022 Feb 7;15(2):204. doi: 10.3390/ph15020204. PMID: 35215314; PMCID: PMC8880557.

55. F. Wang, S. Li, N. Houerbi, and T.F. Chou. Temporal proteomics reveal specific cell cycle oncoprotein downregulation by p97/VCP inhibition. Cell Chem. Biol. 2022, 29(3), 517-529. PMID: 34847375. DOI:


54. K.W. Cheng, S. Li, F. Wang, N.M. Ruiz-Lopez, N. Houerbi, and T.F. Chou. Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication. Cells, 2021, 10(11), 2953. PMID: 34831176. DOI: 10.3390/cells10112953.

53. Q.T. Phan, J. Lin, N.V. Solis, M. Eng, M. Swidergall, F. Wang, S. Li, S.L. Gaffen, T.F. Chou, and S.G. Filler. The Globular C1q Receptor Is Required for Epidermal Growth Factor Receptor Signaling during Candida albicans Infection. mBio, 2021, e0271621. PMID: 34724825. DOI: 10.1128/mBio.02716-21.

52. X. Zhang, L. Gui, S. Li, P. Nandi, R.C. Columbres, D.E. Wong, D.R. Moen, H.J. Lin, P.L. Chiu, and T.F. Chou. Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity. Biochem. J. 2021, 478(17), 3185-3204. PMID: 34405853. DOI: 10.1042/BCJ20210288.

51. P. Nandi, S. Li, R.C.A. Columbres, F. Wang, D.R. Williams, Y.P. Poh, T.F. Chou, and P.L. Chiu. Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes. Int. J. Mol. Sci. 2021, 22(15), 8079. PMID: 34360842. DOI: 10.3390/ijms22158079.

50. A. Wani, J. Zhu, J.D. Ulrich, A. Eteleeb, A.D. Sauerbeck, S.J. Reitz, K. Arhzaouy, C. Ikenaga, C.M. Yuede, S.K. Pittman, F. Wang, S. Li, B.A. Benitez, C. Cruchaga, T.T. Kummer, O. Harari, T.F. Chou, R. Schröder, C.S. Clemen, and C.C. Weihl. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021, 36(3), 109399. PMID: 34289347. DOI: 10.1016/j.celrep.2021.109399.

49. D.E. Michels, B. Lomenick, T.F. Chou, M.J. Sweredoski, and A. Pasulka. Amino Acid Analog Induces Stress Response in Marine Synechococcus. Appl. Environ Microbiol. 2021, 87(15), e0020021. PMID: 33990310. DOI: 10.1128/aem.00200-21.

48. X. Yang, X. Yang, H. Yu, L. Na, T. Ghosh, J.B. McArthur, T.F. Chou, P. Dickson, and X. Chen. A GH89 human α-N-acetylglucosaminidase (hNAGLU) homologue from gut microbe Bacteroides thetaiotaomicron capable of hydrolyzing heparosan oligosaccharides. AMB Express. 2021, 11(1), 94. PMID: 34165649. DOI: 10.1186/s13568-021-01253-1.

47. K.W. Cheng, F. Wang, G.A. Lopez, S. Singamsetty, J. Wood, P.I. Dickson, and T.F. Chou. Evaluation of artificial signal peptides for secretion of two lysosomal enzymes in CHO cells. Biochem. J. 2021, 478(12), 2309-2319. PMID: 34032266. DOI: 10.1042/BCJ20210015.

46. G. Zhang, S. Li, K.W. Cheng, and T.F. Chou. AAA ATPases as Therapeutic Targets: Structure, Function, and Small-Molecule Inhibitors. Eur. J. Med. Chem. 2021, 219, 113446. PMID: 33873056. DOI: 10.1016/j.ejmech.2021.113446.

45. G. Zhang#, S. Li#, F. Wang#, A.C. Jones#, A.F.G. Goldberg, B. Lin, S. Virgil, B.M. Stoltz, R.J. Deshaies#, and T.F. Chou. A Covalent p97/VCP ATPase Inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells. Eur. J. Med. Chem. 2021, 213, 113148. # These authors contributed equally. PMID: 33476933. DOI: 10.1016/j.ejmech.2020.113148.

44. F. Wang, D.R. Moen, C. Sauni, S. Kan, S. Li, S.Q. Le, B. Lomenick, X. Zhang, S. Ekins, S. Singamsetty, J. Wood, P.I. Dickson, and T.F. Chou. Enzyme Replacement Therapy for Mucopolysaccharidosis IIID using Recombinant Human α-N-Acetylglucosamine-6-Sulfatase in Neonatal Mice. Mol Pharm. 2021, 18(1), 214-227. PMID: 33320673. DOI: 10.1021/acs.molpharmaceut.0c00831.


43. Y.C. Chen, M.S. Navarrete, Y. Wang, N.C. McClintock, R. Sakurai, F. Wang, K.T. Chen, T.F. Chou, V.K. Rehan, D.J. Lee, and B. Diaz. N-myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells. Sci. Rep. 2020, 10, 11952. PMID: 32686708. DOI: 10.1038/s41598-020-68615-w.

42. F. Wang, S. Li, T. Gan, G.M. Stott, A. Flint, and T.F. Chou. Allosteric p97 inhibitors can overcome resistance to ATP-competitive p97 inhibitors for potential anti-cancer therapy. ChemMedChem, 2020, 15(8), 685-694. PMID: 32162487. DOI: 10.1002/cmdc.201900722.


41. M.G. LaPorte, J.C. Burnett, R. Colombo, S.L. Bulfer, C. Alverez, T.F. Chou, R.J. Neitz, N. Green, W.J. Moore, Z. Yue, S. Li, M.R. Arkin, P. Wipf, D.M. Huryn. Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. ACS Med. Chem. Lett. 2018, 9(11), 1075-1081. PMID: 30429948. DOI: 10.1021/acsmedchemlett.8b00372.

40. J. Li, Y. Zhang, B. Da Silva Sil Dos Santos, F. Wang, Y. Ma, C. Perez, Y. Yang, J. Peng, S.M. Cohen, T.F. Chou, S.T. Hilton, and R.J. Deshaies. Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11. Cell Chem. Biol. 2018, pii: S2451- 9456(18)30264-2. PMID: 30146242. DOI: 10.1016/j.chembiol.2018.07.012.

39. V. Sanghez, M. Chen, S. Li, T.F. Chou, M. Iacovino, H.J. Lin, J.L. Lasky, and E.H. Panosyan. Efficacy of Asparaginase Erwinia chrysanthemi With and Without Temozolomide Against Glioma Cells and Intracranial Mouse Medulloblastoma. Anticancer Res., 2018, 38, 2627-2634. PMID: 29715082. DOI: 10.21873/anticanres.12504.


38. M.A. Nakasone, T.A. Lewis, O. Walker, A. Thakur, W. Mansour, C.A. Castañeda, J.L. Goeckeler-Fried, F. Parlati, T.F. Chou, O. Hayat, D. Zhang, C.M. Camara, S.M. Bonn, U.K. Nowicka, S. Krueger, M.H. Glickman, J.L. Brodsky, R.J. Deshaies, and D. Fushman. Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway. Structure. 2017, 25, 1839-1855. PMID: 29153505. DOI: 10.1016/j.str.2017.10.007.

37. V. Sanghez, A. Luzzi, D. Clarke, D. Kee, S. Buder, D. Rux, M. Osawa, J. Madrenas, T.F. Chou, M. Kyba, M. Iacovino. Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation. PLoS One, 2017, 12, e0186818. PMID: 29073173. DOI: 10.1371/journal.pone.0186818.

36. C. Perez, J. Li, F. Parlati, M. Rouffet, Y. Ma, H.J. Zhou, A.L. Mackinnon, T.F. Chou, R.J. Deshaies, and S.M. Cohen. Correction to Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J. Med. Chem., 2017; 60(7), 3217. PMID: 28328205. DOI: 10.1021/acs.jmedchem.7b00390.

35. P. Bastola, F. Wang, M.A. Schaich, T. Gan, B.E. Freudenthal, T.F. Chou, and J. Chien. Specific mutations in the D1–D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors. Cell Death Discov., 2017, 60(7), 3217. PMID: 29367883. DOI: 10.1038/cddiscovery.2017.65.

34. R. Shah #, T.F. Chou #, K.M. Maize, A. Strom, B.C. Finzel, and C.R. Wanger. Inhibition by Divalent Metal Ions of Human Histidine Triad Nucleotide Binding Protein1 (hHint1), a Regulator of Opioid Analgesia and Neuropathic Pain. Biochem. Biophys. Res. Commun., 2017, 491, 760-766. # These authors contributed equally. PMID: 28739258. DOI: 10.1016/j.bbrc.2017.07.111.

33. Y.J. Lee, T.F. Chou, S.K. Pittman, and C.C. Weihl. Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA domain Ubiquitination. Cell Rep., 2017, 19,188-202. PMID: 28380357. DOI: 10.1016/j.celrep.2017.03.030.

32. A. Segura-Cabrera, R. Tripathi, X. Zhang, L. Gui, T.F. Chou, and K. Komurov. A structure- and chemical genomics-based approach for repositioning of drugs against VCP/p97 ATPase. Sci. Rep. 2017, 7,44912. PMID: 28322292. DOI: 10.1038/srep44912.

31. C. Perez, J. Li, F. Parlati, M. Rouffet, Y. Ma, A.L. Mackinnon, T.F. Chou, R.J. Deshaies, and S.M. Cohen. Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J. Med. Chem. 2017, 60, 1343-1361. PMID: 28191850. DOI: 10.1021/acs.jmedchem.6b01379.


30. S.L. Bulfer, T.F. Chou, M.R. Arkin. p97 disease mutations modulate nucleotide-induced conformation to alter protein-protein interactions. ACS Chem Biol. 2016, 11, 2112-2116. PMID: 27267671. DOI: 10.1021/acschembio.6b00350.

29. L. Gui, X. Zhang, K. Li, K. Frankowski, S. Li, D. Wong, D.R. Moen, P.R. Porubsky, H.J. Lin, F.J. Schoene, T.F. Chou. Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes. ChemMedChem, 2016, 11, 953-957. PMID: 27043824. DOI: 10.1002/cmdc.201600036.


28. M. Liu, L. Lin, T. Gebremariam, G. Luo, C. D. Skory, S. W. French, T.F, Chou, J.E. Jr. Edwards, and A.S. Ibrahim. Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine. PLoS Pathog. 2015, 11, e1004842. PMID: 25974051. DOI: 10.1371/journal.ppat.1004842.

27. N.U. Jerath, C.D. Crockett, S.A. Moore, M.E. Shy, C.C. Weihl, T.F. Chou, M.A. Gonzalez, S. Zuckner, and A. Swenson. Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation. Case Rep Genet. 2015, 2015, 239167. PMID: 25878907. DOI: 10.1155/2015/239167.

26. X. Zhang, L. Gui, X. Zhang, S. L. Bulfer, V. Sanghez, D. Wong, Y.J. Lee, L. Lehmann, J.S. Lee, P.-Y. Shih, H.J. Lin, M. Iacovino, C.C. Weihl, M.R. Arkin, T. Wang, T.F. Chou. Altered cofactor regulation with disease associated p97/VCP mutations. Proc. Natl. Acad. Sci. USA, 2015, 112, E1705-1714. PMID: 25775548. DOI: 10.1073/pnas.1418820112.

25. C.C. Weihl, R.H. Baloh, Y. Lee, T.F. Chou, S.K. Pittman, G. Lopate, P. Allred, J. Jockel-Balsarotti, A. Pestronk, and M.B. Harms. Targeted sequencing and identification of genetic variants in sporadic inclusion body myositis. Neuromuscul Disord., 2015, 25(4), 289-296. PMID: 25617006. DOI: 10.1016/j.nmd.2014.12.009.

24. C. Fang, L. Gui, X. Zhang, D.R. Moen, K. Li, K.J. Frankowski, H.J. Lin, F.J. Schoene, and T.F. Chou. Evaluating p97 inhibitor analogues for their domain-selectivity and potency against the p97-p47 complex. ChemMedChem, 2015, 10, 52-56. PMID: 25377500. DOI: 10.1002/cmdc.201402420.


23. M. Kato, T.F. Chou, C.Z. Yu, J. Demodena, and P.W. Sternberg. LINKIN, a new transmembrane protein necessary for cell adhesion. eLife. 2014, 3, e04449. PMID: 25437307. DOI: 10.7554/eLife.04449.

22. A. Sapir, A. Tsur, T. Koorman, K. Ching, A. Bardenheier, L. Podolsky, U. Bening-Abu-Shach, M. Boxem, T.F. Chou, L. Broday, and P.W. Sternberg. Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. Proc. Natl. Acad. Sci. USA. 2014, 111, E3880-3889. PMID: 25187565. DOI: 10.1073/pnas.1414748111.

21. M.A. Gonzalez, S. Feely, F. Speziani, A. Strickland, M. Danzi, C. Bacon, Y. Lee, T.F. Chou, S.H. Blanton, C.C. Weihl, S. Zuchner, and M. Shy. A Novel Mutation in VCP Causes Charcot-Marie-Tooth Type 2 Disease. Brain, 2014, 137(11), 2897-2902. PMID: 25125609. DOI: 10.1093/brain/awu224.

20. T.F. Chou*, S. L. Bulfer, C.C. Weihl, K. Li, L.G. Lis, M.A. Walters, F.J. Schoenen, H.J. Lin, R.J. Deshaies, and M.R. Arkin. Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase domains. J. Mol. Biol. 2014, 426, 2886-2899. PMID: 24878061. DOI: 10.1016/j.jmb.2014.05.022.


  1. X. Zhou, T.F. Chou, B.E. Aubol, C.J. Park, R. Wolfenden, J. Adams, and C.R. Wagner. Kinetic Mechanism of Human Histidine Triad Nucleotide Binding Protein 1 (Hint1). Biochemistry, 2013, 52, 3588-3600. PMID: 23614568. DOI: 10.1021/bi301616c.
  2. T.F. Chou*, K. Li, K. Frankowski, F.J. Schoenen, and R.J. Deshaies*. Structure- Activity Relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem. 2013, 8, 297-312. PMID: 23316025. DOI: 10.1002/cmdc.201200520.


  1. S. Bardaweel, B. Ghosh, T.F. Chou, M.J. Sadowsky, and C.R. Wagner. E. coli histidine triad nucleotide binding protein 1 (ecHinT) is a catalytic regulator of D-alanine dehydrogenase (DadA) activity in vivo. PLoS One. 2011, 6, e20897. PMID: 21754980. DOI: 10.1371/journal.pone.0020897.
  2. T.F. Chou*, and R. J. Deshaies*. Development of p97 AAA ATPase inhibitors. Autophagy. 2011, 7, 1091-1092. PMID: 21606684. DOI: 10.4161/auto.7.9.16489.
  3. G. Birkus, N. Kutty, C.R. Frey, R. Shribata, T.F. Chou, C.R. Wagner, M. McDermott, and T. Cihlar. Role of cathepsin A and lysosomes in the intracellular activation of novel anti-papillomavirus agent GS-9191. Antimicrob. Agents Chemother. 2011, 55, 2166 - 2173. PMID: 21383096. DOI: 10.1128/AAC.01603-10.
  4. T.F. Chou*, S. J. Brown, D. Minond, B.E. Nordin, K. Li, A.C. Jones, P. Chase, P. R. Porubsky, B.M. Stoltz, F.J. Schoenen, M.P. Patricelli, P. Hodder, H. Rosen, and R. J Deshaies*. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc. Natl. Acad. Sci. USA. 2011, 108, 4834 - 4839. PMID: 21383145. DOI: 10.1073/pnas.1015312108.
  5. T.F. Chou*, and R.J. Deshaies*. Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. J. Biol. Chem. 2011, 286, 16546 - 16554. PMID: 21343295. DOI: 10.1074/jbc.M110.215319.


  1. S. Bardaweel, J. Pace, T.F. Chou, V. Cody, and C.R. Wagner. Probing the impact of the echinT c-terminal domain on structure and catalysis. J. Mol. Biol. 2010, 404, 627 - 638. PMID: 20934431. DOI: 10.1016/j.jmb.2010.09.066.


  1. J. Cheng, X. Zhou, T.F. Chou, B. Ghosh, B. Liu, and C.R. Wagner. Identification of the amino acid-AZT-phosphoramidase by affinity T7 phage display selection. Bioorg. Med. Chem. Lett. 2009, 19, 6379 - 6381. PMID: 19825512. DOI: 10.1016/j.bmcl.2009.09.067.


  1. T.F. Chou, C. So, B.R. White, J.C.T. Carlson, M. Sarikaya, and C.R. Wagner. Enzyme nanorings. ACS Nano 2008, 2, 2519 - 2525. PMID: 19206287. DOI: 10.1021/nn800577h.
  2. P. Ghosh, J. Chen, T.F. Chou, Y. Jia, S. Avdulov, P. B. Bitterman, V. A. Polunovsky, and C.R. Wagner. Expression, purification and characterization of recombinant mouse initiation factor eIF-4E as a dihydrofolate reductase (DHFR) fusion protein. Protein Expr. Purif., 2008, 60, 132 - 139. PMID:18479935. DOI: 10.1016/j.pep.2008.03.024.


  1. T.F. Chou, Y. Y. Sham, and C. R. Wagner. The Impact of the C-terminal loop of histidine triad nucleotide binding protein1 (Hint1) on substrate specificity. Biochemistry, 2007, 46, 13074 - 13079. PMID:17939685. DOI:10.1021/bi701244h.
  2. T.F. Chou, J. Cheng, I. B. Tikh, and C. R. Wagner. Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily. J. Mol. Biol.2007, 373, 978 - 989. PMID: 17870088. DOI: 10.1016/j.jmb.2007.08.023.
  3. T.F. Chou, I. B. Tikh, B.A.C. Horta, B. Ghosh, R.B. de Alencastro, and C. R. Wagner. Engineered monomeric human histidine triad nucleotide binding protein 1 hydrolyzes fluorogenic acyl -adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate. J. Biol. Chem. 2007, 282, 15137 - 15147. PMID:17337452. DOI:10.1074/jbc.M606972200.
  4. T.F. Chou, J. Baraniak, R. Kaczmarek, X. Zhou, J. Cheng, B. Ghosh, and C. R. Wagner. Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and E. coli histidine triad nucleotide binding proteins (Hint1). Mol. Pharma. 2007, 4, 208 - 217. PMID:17217311. DOI:10.1021/mp060070y.
  5. T.F. Chou and C. R. Wagner. Lysyl-tRNA synthetase generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins (Hints). J. Biol. Chem. 2007, 282, 4719 - 4727. PMID:17158446. DOI:10.1074/jbc.M610530200.


  1. J. C. T. Carlson, S. S. Jena, F. Flenniken, T.F. Chou, R. A. Siegel, and C. R. Wagner. Chemically controlled self-assembly of protein nanorings. J. Am. Chem. Soc. 2006, 128, 7630 - 7638.1. PMID:16756320. DOI:10.1021/ja060631e.


  1. T.F. Chou, Bieganowski, P., Shilinski, K., Cheng, J., Brenner, C., and Wagner, C. R. 31P-NMR and genetic analysis establish hinT as the only Escherichia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions. J. Biol. Chem. 2005, 280, 15356 - 15361. 1. PMID: 15703176 . DOI: 10.1074/jbc.M500434200.


  1. J. Kim, T.F. Chou, Griesgraber, G. W., and Wagner, C. R. Direct measurement of nucleoside monophosphate delivery from a phosphoramidate pronucleotide by stable isotope labeling and LCESI- MS/MS. Mol. Pharm. 2004, 1, 102 - 111. PMID: 15832506. DOI: 10.1021/mp0340338.